What question did this study set out to answer?

To evaluate the onset, duration of sensory and motor blockade, and side-effect profile of intrathecal dexmedetomidine versus magnesium sulfate when combined with bupivacaine for spinal anesthesia.

January 1, 2011Journal of Anaesthesiology Clinical PharmacologyOpen Access

Comparative study of intrathecal dexmedetomidine with intrathecal magnesium sulfate used as adjuvants to bupivacaine

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Authors

DSDeepika Shukla AVAnil Verma AAApurva Agarwal

Discussion

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Overview

Randomized double-blind trial demonstrates faster onset and longer anesthesia with intrathecal dexmedetomidine compared to magnesium sulfate in surgical patients, highlighting its superior efficacy.

Key Points

To evaluate the onset, duration of sensory and motor blockade, and side-effect profile of intrathecal dexmedetomidine versus magnesium sulfate when combined with bupivacaine for spinal anesthesia.
Prospective, randomized, double-blind trial conducted in 90 ASA status I and II patients scheduled for lower abdominal and lower limb surgical procedures.
Patients were randomly allocated to receive 15 mg hyperbaric bupivacaine combined with either 10 μg dexmedetomidine (group D, n=30), 50 mg magnesium sulfate (group M, n=30), or normal saline (group C, n=30).
Onset times to reach peak sensory level and modified Bromage 3 motor block were significantly faster in group D compared with control group C, whereas onset was significantly prolonged in group M (P<0.05).
Total sensory and motor block durations were significantly longest in group D, followed by group M, with both adjuvants outlasting control group C (P<0.05).
Hemodynamic variables remained stable and comparable across all three groups, with no significant adverse events reported.

Cite This Study

Shukla et al. (2011) studied this question.

synapsesocial.com/papers/6a711de9e5469ee92be1bb7c https://doi.org/10.4103/0970-9185.86594

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January 1, 2011Journal of Anaesthesiology Clinical PharmacologyOpen Access

Comparative study of intrathecal dexmedetomidine with intrathecal magnesium sulfate used as adjuvants to bupivacaine

View Full Paper

Ask AI

Bookmark

Authors

DSDeepika Shukla AVAnil Verma AAApurva Agarwal

Discussion

Member takes

Overview

Randomized double-blind trial demonstrates faster onset and longer anesthesia with intrathecal dexmedetomidine compared to magnesium sulfate in surgical patients, highlighting its superior efficacy.

Key Points

To evaluate the onset, duration of sensory and motor blockade, and side-effect profile of intrathecal dexmedetomidine versus magnesium sulfate when combined with bupivacaine for spinal anesthesia.
Prospective, randomized, double-blind trial conducted in 90 ASA status I and II patients scheduled for lower abdominal and lower limb surgical procedures.
Patients were randomly allocated to receive 15 mg hyperbaric bupivacaine combined with either 10 μg dexmedetomidine (group D, n=30), 50 mg magnesium sulfate (group M, n=30), or normal saline (group C, n=30).
Onset times to reach peak sensory level and modified Bromage 3 motor block were significantly faster in group D compared with control group C, whereas onset was significantly prolonged in group M (P<0.05).
Total sensory and motor block durations were significantly longest in group D, followed by group M, with both adjuvants outlasting control group C (P<0.05).
Hemodynamic variables remained stable and comparable across all three groups, with no significant adverse events reported.

Cite This Study

Shukla et al. (2011) studied this question.

synapsesocial.com/papers/6a711de9e5469ee92be1bb7c https://doi.org/10.4103/0970-9185.86594

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