This review suggests that nitric oxide plays only a modest obligatory role in controlling exercising muscle blood flow, highlighting the need for further research into the synergistic mechanisms of exercise hyperemia.
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Questions modest obligatory role of nitric oxide in exercise hyperemia; leaves open dominant synergistic mechanisms for targeted study.
Despite being the subject of investigation for well over 100 years, the nature of exercising muscle blood flow control remains, in many respects, poorly understood. In this review we focus on the potential role of nitric oxide in vasodilation of muscle resistance vessels during a bout of exercise. Its contribution is explored in the context of whether it contributes to steady-state exercise hyperemia, the dynamic adjustment of muscle blood flow to exercise, or the modulation of sympathetic vasoconstriction in exercising muscle. It appears that the obligatory role of nitric oxide in all three of these categories is modest at best. The elucidation of the integrated nature of exercise hyperemia control in terms of synergy and redundancy of mechanism interaction remains in its infancy, and much more remains to be learned about the role of nitric oxide in this type of integrated control.
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Tschakovsky et al. (2008) studied this question.
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