Addition of 24‐Hour Heart Rate Variability Parameters to the Cardiovascular Health Study Stroke Risk Score and Prediction of Incident Stroke: The Cardiovascular Health Study
Why the study?
Does the addition of 24-hour heart rate variability parameters to the CHS clinical stroke risk score improve the prediction of incident stroke in older adults?
Population
884 stroke-free older adults from the Cardiovascular Health Study with 24-hour Holters adequate for heart…
Comparison
Addition of 24-hour heart rate variability… vs Cardiovascular Health Study clinical stroke risk…
Design
Cohort
Follow-up
median 7.3 [interquartile range 7.1–7.6] years
Authors
Discussion
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Member takes
Implication
Certain 24-hour HRV parameters may refine stroke prediction in older adults; leaves open whether they warrant clinical adoption pending validation.
Structured PICO
Does the addition of 24-hour heart rate variability parameters to the CHS clinical stroke risk score improve the prediction of incident stroke in older adults?
P
Population
884 stroke-free older adults (mean age 75.3±4.6) from the Cardiovascular Health Study with 24-hour Holters adequate for heart rate variability analysis
I
Intervention
Addition of 24-hour heart rate variability (HRV) parameters (coefficient of variance of NN intervals [CV%] and power law slope) to the Cardiovascular Health Study clinical stroke risk score (CHS-SCORE)
C
Comparator
Cardiovascular Health Study clinical stroke risk score (CHS-SCORE) alone
O
Outcome
Incident stroke over ≤8 year follow-uphard clinical
The addition of specific 24-hour heart rate variability parameters to a validated clinical risk score may improve the prediction of incident stroke in older adults.
Limitations
- Findings will require validation in separate, larger cohorts
Cite This Study
Bodapati et al. (2017) studied this question.