February 1, 1984Epilepsia

Sudden Unexpected Death Associated with Seizures: Analysis of 66 Cases

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Population

66 cases of sudden unexpected death in persons with seizure disorders, age 10 months to 60 years, examined…

Design

Case_series

Authors

JLJan E. LeestmaNorthwestern University MKMitra B. KalelkarNorthwestern University STShaku S. TeasNorthwestern University

Discussion

Member takes

Implication

Subtherapeutic anticonvulsant levels may raise SUDEP risk via arrhythmias; case reports leave mechanisms open for prospective study.

Structured PICO

Population

66 cases of sudden unexpected death (SUD) in persons with seizure disorders, age 10 months to 60 years (mean age 28 years), examined by the Office of the Medical Examiner, Cook County (Chicago), Illinois.

Outcome

Autopsy findings, circumstances of death, neuropathological findings, and anticonvulsant blood levels

Sudden unexpected death in epilepsy is frequently associated with subtherapeutic anticonvulsant levels and may involve cardiac arrhythmias mediated by sympathetic autonomic events during seizures.

Cite This Study

Leestma et al. (1984) studied this question.

synapsesocial.com/papers/6a71208bc2d7c309082703f1 https://doi.org/10.1111/j.1528-1157.1984.tb04159.x

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February 1, 1984Epilepsia

Sudden Unexpected Death Associated with Seizures: Analysis of 66 Cases

View Full Paper

Ask AI

Bookmark

Population

66 cases of sudden unexpected death in persons with seizure disorders, age 10 months to 60 years, examined…

Design

Case_series

Authors

JLJan E. LeestmaNorthwestern University MKMitra B. KalelkarNorthwestern University STShaku S. TeasNorthwestern University

Discussion

Member takes

Implication

Subtherapeutic anticonvulsant levels may raise SUDEP risk via arrhythmias; case reports leave mechanisms open for prospective study.

Structured PICO

Population

Outcome

Autopsy findings, circumstances of death, neuropathological findings, and anticonvulsant blood levels

Sudden unexpected death in epilepsy is frequently associated with subtherapeutic anticonvulsant levels and may involve cardiac arrhythmias mediated by sympathetic autonomic events during seizures.

Cite This Study

Leestma et al. (1984) studied this question.

synapsesocial.com/papers/6a71208bc2d7c309082703f1 https://doi.org/10.1111/j.1528-1157.1984.tb04159.x

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