What question did this study set out to answer?

To critically evaluate evidence linking impaired nitric oxide production to increased vascular smooth muscle cell proliferation and delineate the underlying molecular mechanisms.

August 15, 1999Cardiovascular ResearchOpen Access

Nitric oxide and the proliferation of vascular smooth muscle cells

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To critically evaluate evidence linking impaired nitric oxide production to increased vascular smooth muscle cell proliferation and delineate the underlying molecular mechanisms.
Reviewed in vitro studies assessing the effects of nitric oxide donors, cyclic guanosine monophosphate analogues, and cell cycle regulators in cultured vascular smooth muscle cells.
Analyzed animal models of balloon catheter injury, vein grafting, and hypercholesterolemia examining nitric oxide synthase expression and reactive oxygen species interactions.
Evaluated outcomes from pharmacological nitric oxide donor administration and nitric oxide synthase gene transfer experiments targeting vascular remodeling.
Nitric oxide donors and cyclic guanosine monophosphate analogues inhibit vascular smooth muscle cell proliferation by arresting the cell cycle at G1-S phase and promoting apoptosis.
Vessel wall injury impairs endothelial nitric oxide synthase activity while inducing smooth muscle inducible nitric oxide synthase expression and increasing superoxide generation.
Superoxide quenches bioavailable nitric oxide to form reactive peroxynitrite, whereas recombinant endothelial or inducible nitric oxide synthase gene transfer markedly suppresses neointimal hyperplasia.

Design

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Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support NO-based strategies against restenosis; leaves open clinical translation pending prospective trials.

Cite This Study

J.Y. Jeremy (1999) studied this question.

synapsesocial.com/papers/6a7123de75498292b70a9fbf https://doi.org/10.1016/s0008-6363(99)00171-6

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Nitric oxide and the proliferation of vascular smooth muscle cells

Key Points

Discussion

Implication

Cite This Study

Nitric oxide and the proliferation of vascular smooth muscle cells

Key Points

Discussion

Implication

Cite This Study

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