Why the study?
There is a need to determine potential damage within muscle tissue when repeated muscle sampling is part of the study design.
Does short-term repeated human biopsy sampling cause changes in muscle morphology and higher outcome variability?
Does short-term repeated human biopsy sampling cause changes in muscle morphology and higher outcome variability?
Repeated muscle biopsy sampling can induce muscle damage and increase data heterogeneity, which must be accounted for in study designs.
Repeated biopsy sampling may confound muscle data via induced damage; leaves open optimal protocols and requires methodological validation.
Indices of damage can be found in repeated biopsy samples of nonintervened control legs. Variables, directly and not directly related to muscle damage or regeneration, were compromised in second biopsy. There is a need to determine potential damage within muscle tissue when repeated muscle sampling is part of the study design. Muscle biopsy sampling may be a source of increased heterogeneity in human muscle data.
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Long et al. (2023) studied this question.
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