Why the study?
Little is known about methodological or biological variation stemming from the percutaneous muscle biopsy technique in heterogeneous muscle.
Does repeated percutaneous muscle biopsy sampling in the vastus lateralis show variability in myofibre characteristics and capillarization?
Population
29 young men (22 ± 1 years)
Comparison
Five muscle biopsies from the vastus lateralis over a 96-h period
Follow-up
96-h period
Authors
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Biopsy sampling appears reliable for research in healthy muscle; leaves open validation in clinical or diseased populations.
Does repeated percutaneous muscle biopsy sampling in the vastus lateralis show variability in myofibre characteristics and capillarization?
Myofibre characteristics and indices of capillarization are largely consistent across multiple biopsy sites in the human vastus lateralis, provided at least 150 muscle fibres are quantified.
Nederveen et al. (2020) studied this question.
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