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In Brief Primary care may be the first and only treatment setting for patients suffering from major depressive disorder (MDD). Often difficult to recognize, MDD can be mistaken for or masked by reactive sadness, grief, a reaction to medication, or a comorbid condition. The nurse practitioner can play a crucial role in the early identification, treatment, and management of MDD (as classified in the Diagnostic Statistical Manual IV-Text Revision).
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Thayer et al. (2006) studied this question.
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