What question did this study set out to answer?

July 1, 1996Pancreas

Prevention of Recurrent Acute Pancreatitis in Patients with Severe Hypertriglyceridemia

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Why the study?

Does plasmapheresis prevent recurrent acute pancreatitis in patients with severe hypertriglyceridemia?

Population

2 patients with severe primary hypertriglyceridemia and recurrent acute pancreatitis, refractory to diet and…

Design

Case_series

Authors

APAlain PiolotInserm FNFrédéric NadlerRiverview Psychiatric Center ECElizabeth CavalleroHospital Ramos Mejía

Discussion

Member takes

Implication

May support use in refractory hypertriglyceridemia; hypothesis-generating without controlled data.

Key Points

Evaluate the efficacy and safety of regular plasmapheresis in preventing recurrent acute pancreatitis in patients with severe primary hypertriglyceridemia refractory to standard medical management.
Evaluated 2 patients (N=2) with severe primary hypertriglyceridemia (types I and V) experiencing recurrent acute pancreatitis despite dietary modifications and drug therapy.
Administered maintenance plasmapheresis every 4 weeks to clear circulating serum lipids.
Plasmapheresis provided a safe and highly effective method for rapidly clearing elevated serum triglyceride levels.
Scheduled plasmapheresis every 4 weeks successfully reduced the incidence of recurrent acute pancreatitis triggered by dietary fat or alcohol exposure.

Structured PICO

Does plasmapheresis prevent recurrent acute pancreatitis in patients with severe hypertriglyceridemia?

Population

2 patients with severe primary hypertriglyceridemia (types 1 and V) and recurrent acute pancreatitis, refractory to diet and drug therapy

Intervention

Plasmapheresis every 4 weeks

Outcome

Incidence of recurrent acute pancreatitis and removal of serum triglycerides

Plasmapheresis every 4 weeks may be a safe and effective method to prevent recurrent acute pancreatitis in patients with severe hypertriglyceridemia refractory to standard therapy.

Cite This Study

Piolot et al. (1996) studied this question.

synapsesocial.com/papers/6a7125e8fe4101aa97e07407 https://doi.org/10.1097/00006676-199607000-00013

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Prevention of Recurrent Acute Pancreatitis in Patients with Severe Hypertriglyceridemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Prevention of Recurrent Acute Pancreatitis in Patients with Severe Hypertriglyceridemia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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