Why the study?
Does polycystic ovary syndrome worsen endothelial function in overweight women compared to BMI-matched controls?
Population
107 overweight and obese age- and BMI-matched women with and without polycystic ovary syndrome.
Comparison
Polycystic ovary syndrome (PCOS) vs Without PCOS (age- and BMI-matched controls)
Design
Cross-sectional
Authors
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May indicate higher CV risk in PCOS; hypothesis-generating for endothelial markers, prospective studies needed.
Does polycystic ovary syndrome worsen endothelial function in overweight women compared to BMI-matched controls?
Overweight women with PCOS exhibit increased circulating markers of endothelial dysfunction (ADMA and PAI-1) and insulin resistance compared to BMI-matched controls, indicating higher cardiovascular risk.
Moran et al. (2008) studied this question.
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