Key result
Recent cerebral ischemia linked to ~1-point higher leukocyte aggregation vs controls.
Case-Control (n=122)
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BACKGROUND AND PURPOSE: The role of leukocyte aggregation in ischemic stroke is controversial. In this study we investigated this hemorheologic alteration in patients at risk for stroke. METHODS: Leukocyte aggregation was evaluated with the leukergy test in 61 patients with a recent cerebral ischemic event and in 61 control subjects. RESULTS: In patients leukocyte aggregation was significantly higher than in control subjects (3.8 +/- 3.4% versus 2.5 +/- 2.2%; P = .01). In control subjects, the presence of vascular risk factors was associated with values of aggregation similar to those observed in patients. CONCLUSIONS: These findings suggest an association between altered leukocyte aggregation and cerebrovascular disease. Further investigations are needed to evaluate whether this hemorheologic alteration can be considered a marker of increased risk for stroke.
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Silvestrini et al. (1994) conducted a case-control in Recent cerebral ischemic event / Ischemic stroke (n=122). Recent cerebral ischemic event vs. Control subjects was evaluated on Leukocyte aggregation evaluated with the leukergy test (p=0.01). Patients with a recent cerebral ischemic event had significantly higher leukocyte aggregation than control subjects (3.8% vs 2.5%; P=0.01).
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