What question did this study set out to answer?

To examine the effects of moderate hyperglycemia on blood-brain barrier permeability after normothermic and hypothermic global forebrain ischemia.

January 1, 1993StrokeOpen Access

Moderate hyperglycemia worsens acute blood-brain barrier injury after forebrain ischemia in rats.

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Authors

WDW. Dalton DietrichCURE International UK OAOfelia F. AlonsoUniversity of Miami RBRaul BustoUnited States Department of Veterans Affairs

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Implication

Animal study reveals that moderate hyperglycemia exacerbates blood-brain barrier injury after forebrain ischemia in rats, indicating that vascular breakdown drives glucose-related brain damage.

Key Points

To examine the effects of moderate hyperglycemia on blood-brain barrier permeability after normothermic and hypothermic global forebrain ischemia.
Sixteen rats underwent 20 minutes of four-vessel occlusion followed by 30 minutes of reperfusion under normothermic (37°C) or hypothermic (30°C) conditions.
Moderate hyperglycemia was induced using an intraperitoneal injection of 50% dextrose 15 minutes before ischemia, and horseradish peroxidase was administered as a vascular permeability tracer.
Hyperglycemic rats (plasma glucose 342 ± 27 mg/dl) developed severe, widespread horseradish peroxidase leakage throughout the cortex, striatum, hippocampus, thalamus, and cerebellum, compared to normoglycemic rats (115 ± 3 mg/dl) where leakage was mainly restricted to the cerebral cortex.
Intraischemic hypothermia significantly attenuated the extensive blood-brain barrier breakdown observed during hyperglycemic brain ischemia.

Cite This Study

Dietrich et al. (1993) studied this question.

synapsesocial.com/papers/6a712a59660549caf2c5cb3a https://doi.org/10.1161/01.str.24.1.111

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Implication

Animal study reveals that moderate hyperglycemia exacerbates blood-brain barrier injury after forebrain ischemia in rats, indicating that vascular breakdown drives glucose-related brain damage.

Moderate hyperglycemia worsens acute blood-brain barrier injury after forebrain ischemia in rats.

Discussion

Member takes

Implication

Key Points

Cite This Study

Moderate hyperglycemia worsens acute blood-brain barrier injury after forebrain ischemia in rats.

Discussion

Member takes

Implication

Key Points

Cite This Study

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