What question did this study set out to answer?

To review the evolving clinical indications, diagnostic monitoring, physiological effects, and survival outcomes of lung and heart-lung transplantation.

May 1, 1990European Respiratory JournalOpen Access

Transplantation of the lung

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Authors

THT HigenbottamPapworth Hospital BOBA Otulana JWJ Wallwork

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Implication

Clinical review demonstrates improved outcomes for severe cardiopulmonary diseases via lung transplantation, highlighting persistent challenges from rejection and infection.

Key Points

To review the evolving clinical indications, diagnostic monitoring, physiological effects, and survival outcomes of lung and heart-lung transplantation.
Synthesized clinical indications, contra-indications, and surgical approaches for heart-lung and lung transplantation supported by cyclosporine immunosuppression.
Evaluated physiological monitoring techniques and diagnostic approaches for major post-transplant complications, including pulmonary rejection and denervation.
Heart-lung transplantation offers effective management for end-stage suppurative disorders like cystic fibrosis, with three-year survival rates exceeding 50%.
Obliterative bronchiolitis resulting from repeated and severe pulmonary rejection remains a critical clinical barrier following surgery.
Disruption of normal pulmonary innervation and vascular supply alters breathing regulation and respiratory mechanics, offering new insights into disease pathogenesis.

Cite This Study

Higenbottam et al. (1990) studied this question.

synapsesocial.com/papers/6a712a59ac440176ef29d8a8 https://doi.org/10.1183/09031936.93.03050594

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Implication

Clinical review demonstrates improved outcomes for severe cardiopulmonary diseases via lung transplantation, highlighting persistent challenges from rejection and infection.

Transplantation of the lung

Discussion

Member takes

Implication

Key Points

Cite This Study

Transplantation of the lung

Discussion

Member takes

Implication

Key Points

Cite This Study

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