August 1, 2009European Journal of Immunology
Animal models of rheumatoid arthritis
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Implication
Narrative review outlines induced and genetic rodent models of rheumatoid arthritis, highlighting their mechanisms, utility, and translational limitations.
Key Points
- Review induced and spontaneous rodent models of rheumatoid arthritis to evaluate their utility, advantages, and limitations in studying disease pathogenesis and therapeutic development.
- Reviewed chemically and immunologically induced rodent models, including collagen-induced, collagen-antibody-induced, zymosan-induced, and methylated bovine serum albumin models.
- Assessed spontaneous and genetically engineered rodent systems, such as tumor necrosis factor-alpha transgenic, K/BxN, and Skg mice.
- Rodent models have clarified core cellular and molecular mechanisms driving rheumatoid arthritis, directly contributing to major advances in clinical treatment.
- Each model reproduces specific facets of human rheumatoid arthritis pathogenesis, balanced by distinct inherent physiological limitations.
Cite This Study
Asquith et al. (2009) studied this question.