Key result
Familial Type II hyperlipoproteinaemia is linked to higher plasma fibrinogen and platelet aggregates versus controls.
Case-Control (n=42)
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Plasma fibrinogen and platelet-aggregates (method of Wu and Hoak) were measured in 21 patients with familial Type II hyperlipoproteinemia and 21 matched control subjects. Patients with hyperlipoproteinaemia had increased levels of fibrinogen and platelet-aggregates (p less than 0.01). Young patients with hyperlipoproteinaemia had prematurely high fibrinogen levels, and the normal rise in fibrinogen during adult life was abolished. There were no statistically significant correlations within the patient group between fibrinogen, platelet-aggregates, and plasma lipids. High fibrinogen and platelet-aggregate levels may play a part in the development of the premature arterial disease associated with Type II hyperlipoproteinaemia, or may be markers of arterial injury.
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Lowe et al. (1979) conducted a case-control in Familial Type II hyperlipoproteinaemia (n=42). Familial Type II hyperlipoproteinaemia vs. Matched control subjects was evaluated on Plasma fibrinogen and platelet-aggregate levels (p=<0.01). Familial Type II hyperlipoproteinaemia was associated with increased levels of plasma fibrinogen and platelet-aggregates compared to matched controls.
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