Why the study?
Does WT1 antibody staining reliably differentiate DSRCT from EWS/PNET in malignant small round cell tumors?
Population
24 malignant small round cell tumors previously diagnosed as desmoplastic small round cell tumor or Ewing…
Comparison
Immunohistochemistry with an antibody to the… vs Reverse transcriptase-polymerase chain reaction…
Design
Other
Authors
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Supports WT1 IHC for DSRCT vs EWS/PNET differentiation when genetics unavailable; leaves open validation in larger prospective series.
Does WT1 antibody staining reliably differentiate DSRCT from EWS/PNET in malignant small round cell tumors?
WT1 antibody staining is highly sensitive and specific for differentiating DSRCT from EWS/PNET, serving as a useful diagnostic tool when genetic information is unavailable.
Hill et al. (2000) studied this question.
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