Clinical, Metabolic and Cardiovascular Effects of Different Prostaglandins in Man

Prostaglandin A 1 (PGA 1 ), PGE 2 , PGF 1α , PGF 1β , and PGF 2α have been infused intravenously into nine healthy male subjects. PGA 1 was given to three subjects in doses from 0.056 to 0.56 μg/kg/min. In one of these subjects a slight flush was seen. The heart rate tended to increase without significant change in blood pressure. The levels of free fatty acids (FFA) in plasma increased slightly. PGE 2 was given to two subjects in doses from 0.056 to 0.56 μg/kg/min. A flush was seen in all four subjects given PGE 2 , and the other effects were also similar to those previously seen with PGE 1 . Thus an increase in heart rate and of plasma FFA levels occurred. With the prostaglandins of the F‐series in doses up to 0.32 or 0.56 μg/kg/min, no clinical effects were noted. There were no significant changes in heart rate, blood pressure or plasma FFA levels.