What question did this study set out to answer?

Assess the acute cardiovascular and subjective physiological effects of intravenous prostaglandin E infusion in humans.

April 1, 1959Acta Physiologica Scandinavica

Observations on the Effects of Infusion of Prostnglnndin E in Man

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Authors

SBS. BERGBTRÖMKarolinska University Hospital HDH. DTJNGRKarolinska University Hospital UEU. S. von EulerKarolinska University Hospital

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Implication

Experimental study demonstrates reduced arterial blood pressure and cardiac output alongside tachycardia in healthy men, indicating potent cardiovascular effects of prostaglandin E.

Key Points

Assess the acute cardiovascular and subjective physiological effects of intravenous prostaglandin E infusion in humans.
Infused chemically pure prostaglandin E at doses of 0.2–4.7 μg/kg/min over periods of 4–10 minutes.
Administered the infusion to two healthy male subjects (N=2) while monitoring hemodynamic responses.
Induced tachycardia, facial reddening, headache, and an oppressive feeling in the chest.
Systemic arterial blood pressure and cardiac output fell moderately during the infusion period.

Cite This Study

BERGBTRÖM et al. (1959) studied this question.

synapsesocial.com/papers/6a72d581f271d72d3a303c23 https://doi.org/10.1111/j.1748-1716.1959.tb01686.x

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Implication

Experimental study demonstrates reduced arterial blood pressure and cardiac output alongside tachycardia in healthy men, indicating potent cardiovascular effects of prostaglandin E.

Observations on the Effects of Infusion of Prostnglnndin E in Man

Discussion

Member takes

Implication

Key Points

Cite This Study

Observations on the Effects of Infusion of Prostnglnndin E in Man

Discussion

Member takes

Implication

Key Points

Cite This Study

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