Key result
Intravenous infusion of prostacyclin in healthy men almost doubled cardiac output and halved total systemic vascular resistance, but did not significantly alter forearm blood flow.
Why the study?
Does intravenous prostacyclin infusion alter cardiac output and forearm blood flow in healthy men?
Population
8 healthy male volunteers
Follow-up
During intravenous infusion
Authors
Loading...
Supports dissimilar vasoactive potency of prostacyclin across systemic beds; hypothesis-generating for targeted vasodilator therapy.
Does intravenous prostacyclin infusion alter cardiac output and forearm blood flow in healthy men?
Prostacyclin acts as a potent pulmonary and systemic vasodilator but exhibits dissimilar vasoactive potency across different systemic vascular beds, such as the forearm.
Eklund et al. (1981) studied Healthy (n=8). Prostacyclin was evaluated on Cardiac output, forearm blood flow, and vascular resistance. Intravenous infusion of prostacyclin in healthy men almost doubled cardiac output and halved total systemic vascular resistance, but did not significantly alter forearm blood flow.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: