Key result
Infusion of prostacyclin led to a distinct fall in peripheral and total pulmonary vascular resistances, accompanied by a drop in blood pressure and acceleration of heart rate.
Why the study?
Does prostacyclin infusion alter haemodynamic parameters in subjects without coronary heart disease or cardiac failure?
Does prostacyclin infusion alter haemodynamic parameters in subjects without coronary heart disease or cardiac failure?
Prostacyclin acts predominantly on resistance vessels, lowering peripheral and pulmonary vascular resistance, suggesting potential utility in conditions with elevated vascular resistance.
Should not change practice in normal subjects; leaves open vasodilator role in elevated-resistance states pending controlled trials.
Intra-arterial or intravenous infusion of prostacyclin at three dose levels (2, 5, and 10 ng/kg per min) in 10 subjects without evidence of coronary heart disease or cardiac failure, led to a distinct fall in peripheral and total pulmonary vascular resistances. This was accompanied by a drop in intra-arterial blood pressure, and the acceleration of heart rate. Stroke volume, cardiac output, mean right atrial pressure, and left ventricular end-diastolic pressure showed no significant changes. Except for sporadic headache no side effects occurred. Prostacyclin appears to act predominantly on resistance vessels. The haemodynamic effects produced by prostacyclin in man might be of clinical interest in the treatment of conditions associated with a significant rise in vascular resistance.
No takes yet. Share an insight, caveat, or question.
Szczeklik et al. (1980) studied Without evidence of coronary heart disease or cardiac failure (n=10). Prostacyclin was evaluated on Peripheral and total pulmonary vascular resistances. Infusion of prostacyclin led to a distinct fall in peripheral and total pulmonary vascular resistances, accompanied by a drop in blood pressure and acceleration of heart rate.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: