Why the study?
Does prostacyclin infusion preserve platelet count and function in adult patients undergoing cardiopulmonary bypass?
Population
45 adult patients operated on for acquired heart disease requiring cardiopulmonary bypass (CPB)
Comparison
Prostacyclin infusion vs Control group receiving standard cardiopulmonary…
Design
Cohort
Follow-up
Intra- and post-operative
Authors
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Should not change practice; observational data leaves open need for RCTs balancing platelet effects against hemodynamic risks.
Does prostacyclin infusion preserve platelet count and function in adult patients undergoing cardiopulmonary bypass?
Prostacyclin infusion during cardiopulmonary bypass significantly preserves platelet count and function but is associated with marked reductions in aortic blood pressure and systemic vascular resistance.
Rådegran et al. (1981) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: