Why the study?
Does prostacyclin infusion reduce platelet activation in patients requiring open heart surgery with cardiopulmonary bypass?
Population
48 patients requiring open heart surgery with cardiopulmonary bypass
Comparison
Prostacyclin infused at a dose of 20 ng/kg/min… vs Placebo
Design
RCT, double-blind
Follow-up
immediate post-operative period
Authors
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Supports prostacyclin during CPB to limit platelet activation; confirms RCT benefit on preservation.
Does prostacyclin infusion reduce platelet activation in patients requiring open heart surgery with cardiopulmonary bypass?
Prostacyclin infusion during cardiopulmonary bypass decreases platelet activation, preserving platelet counts and reducing secretory protein release.
Walker et al. (1981) studied this question.
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