Key result
Prostacyclin plus heparin preserves platelets and reduces blood loss vs heparin alone during cardiopulmonary bypass.
Why the study?
Does prostacyclin combined with heparin improve platelet preservation and reduce blood loss in patients undergoing cardiopulmonary bypass compared to heparin alone?
Population
24 patients undergoing coronary vein grafts (along with experimental dog models)
Comparison
Prostacyclin (PGI2) combined with heparin vs Heparin alone
Design
RCT, double-blind
Authors
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Supports combining prostacyclin with heparin in cardiopulmonary bypass to reduce bleeding; extends canine platelet data to this human RCT.
RCT (n=24)
Double-blind
Does prostacyclin combined with heparin improve platelet preservation and reduce blood loss in patients undergoing cardiopulmonary bypass compared to heparin alone?
The addition of prostacyclin to heparin during cardiopulmonary bypass preserves platelet function and reduces blood loss.
Longmore Db (1981) conducted an RCT in Patients undergoing coronary vein grafts (n=24). Prostacyclin (PGI2) combined with heparin vs. Heparin alone was evaluated on Platelet numbers, aggregability, and blood loss. In a trial of 24 patients, prostacyclin combined with heparin preserved platelet numbers and aggregability and reduced blood loss compared to heparin alone during cardiopulmonary bypass.
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