Key result
Intra-arterial PGE1 lowers leg BP but fails to increase distal blood flow in occlusive arterial disease.
Why the study?
Does intra-arterial infusion of prostaglandin E1 improve distal blood flow in patients with occlusive arterial disease of the legs?
Population
6 patients with occlusive arterial disease of the legs and 3 normal subjects (n=9)
Comparison
Intra-arterial infusion of prostaglandin E1 in… vs Normal subjects
Design
Other
Follow-up
Acute
Authors
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Failed to increase distal flow in occlusive disease; leaves open alternative mechanisms for reported rest-pain relief.
Does intra-arterial infusion of prostaglandin E1 improve distal blood flow in patients with occlusive arterial disease of the legs?
Intra-arterial PGE1 fails to increase distal blood flow in patients with peripheral arterial disease, suggesting alternative mechanisms for its reported efficacy in ischemic rest pain.
Nielsen et al. (1976) studied Peripheral Arterial Disease (n=9). Intra-arterial infusion of prostaglandin E1 (PGE1) vs. Normal subjects was evaluated on Blood flow and blood pressure at different segments of the leg. Intra-arterial infusion of prostaglandin E1 decreased leg blood pressure in all subjects, but failed to increase distal blood flow in patients with occlusive arterial disease.
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