Why the study?
Does intravenous prostaglandin E1 improve rest pain or promote ulcer healing in patients with severe lower limb ischaemia due to atherosclerosis?
Does intravenous prostaglandin E1 improve rest pain or promote ulcer healing in patients with severe lower limb ischaemia due to atherosclerosis?
Intravenous prostaglandin E1 does not improve rest pain or promote ulcer healing in patients with end-stage lower limb atherosclerotic disease.
Argues against PGE1 for rest pain or ulcers in severe limb ischemia; challenges earlier non-randomized reports and questions its guideline role.
Thirty patients with ischaemic ulceration or rest pain due to lower limb atherosclerosis were treated with intravenous prostaglandin E1 (PGE1) or placebo in a prospective double-blind controlled trial. There was no significant improvement of rest pain, nor was PGE1 effective in promoting ulcer healing. This study provides no support for the use of intravenous PGE1 in the treatment of end-stage lower limb atherosclerotic disease.
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Telles et al. (1984) studied this question.
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