Why the study?
Does intra-arterial administration of prostaglandin E1 improve haemodynamic effects compared to intravenous administration in patients with peripheral arterial disease?
Population
Patients with peripheral arterial disease (ischaemic legs)
Comparison
Intra-arterial administration of prostaglandin E1 vs Intravenous administration of prostaglandin E1
Design
Other
Authors
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May support intra-arterial over intravenous PGE1 for local perfusion in PAD; hypothesis-generating, requires RCTs before practice change.
Does intra-arterial administration of prostaglandin E1 improve haemodynamic effects compared to intravenous administration in patients with peripheral arterial disease?
Continuous intra-arterial infusion of prostaglandin E1 provides superior haemodynamic improvements in ischaemic legs compared to intravenous administration in patients with peripheral arterial disease.
Hirai et al. (1986) studied this question.
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