What question did this study set out to answer?

To review the mechanisms through which free radicals induce tissue damage and evaluate the protective functions of endogenous enzymes and dietary antioxidant nutrients.

December 1, 1987The FASEB Journal

Free radical tissue damage: protective role of antioxidant nutrients 1

View Full Paper

Ask AI

Bookmark

Authors

LMLawrence J. MachlinRoche (Switzerland)ABAdrianne BendichRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Narrative review highlights how dietary antioxidants counteract free radical tissue damage in humans, suggesting targeted nutritional support protects against chronic disease.

Key Points

To review the mechanisms through which free radicals induce tissue damage and evaluate the protective functions of endogenous enzymes and dietary antioxidant nutrients.
Synthesized evidence on endogenous metabolic sources and exogenous environmental triggers (radiation, tobacco smoke, air pollutants, solvents, pesticides) of free radical generation.
Evaluated physiological defense systems, including antioxidant micronutrients (vitamins C and E, beta-carotene) and metalloenzymes (glutathione peroxidase, catalase, superoxide dismutase).
Free radicals cause widespread cellular damage by targeting polyunsaturated fatty acids in membranes, DNA nucleotides, and critical protein sulfhydryl bonds.
Oxidative tissue damage contributes directly to chronic conditions, including cardiovascular disease, cancer, emphysema, cataracts, and inflammatory disorders.
Overall tissue preservation depends on the dynamic balance between free radical generation and defense from dietary micronutrients and antioxidant metalloenzymes.

Cite This Study

Machlin et al. (1987) studied this question.

synapsesocial.com/papers/6a713041ac440176ef29decb https://doi.org/10.1096/fasebj.1.6.3315807

View Full Paper

Ask AI

Bookmark

Implication

Narrative review highlights how dietary antioxidants counteract free radical tissue damage in humans, suggesting targeted nutritional support protects against chronic disease.

Free radical tissue damage: protective role of antioxidant nutrients 1

Discussion

Member takes

Implication

Key Points

Cite This Study

Free radical tissue damage: protective role of antioxidant nutrients 1

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider