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Interleukin-1 beta dose- and time-dependently upregulates endothelin receptor expression and mRNA in human VSMCs.
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Endothelin may play a role in atherosclerosis as it causes smooth muscle cell proliferation and its levels are elevated in patients with atherosclerosis. We report that interleukin-1 beta is a potent inducer of endothelin receptor expression in cultured human vascular smooth muscle cells. The effect is dose- and time-dependent and is due to an increase in receptor number. Endothelin receptor mRNA levels are also elevated. Interleukin-1 beta is a major regulator of endothelin release so, together with its effects on endothelin receptors, it may be responsible for a generalized activation of the endothelin system in diseased vessels.
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Newman et al. (1995) studied Atherosclerosis. Interleukin-1 beta was evaluated on Endothelin receptor expression and mRNA levels. Interleukin-1 beta dose- and time-dependently induced endothelin receptor expression and elevated mRNA levels in cultured human vascular smooth muscle cells.
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