May 1, 1995AJP Cell Physiology
Vascular smooth muscle cell migration mediated by thrombin and urokinase receptor
Why the study?
Does alpha-thrombin stimulate migration and proliferation in vascular smooth muscle cells?
Population
Vascular smooth muscle cells (SMC) in Transwell systems (modified Boyden chambers)
Comparison
Exposure to alpha-thrombin vs gamma-thrombin or PPACK-inactivated alpha-thrombin
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Suggests thrombin-uPAR axis as restenosis target; leaves open confirmation in human trials.
Structured PICO
Does alpha-thrombin stimulate migration and proliferation in vascular smooth muscle cells?
P
Population
Vascular smooth muscle cells (SMC) in Transwell systems (modified Boyden chambers)
I
Intervention
Exposure to alpha-thrombin (concentrations as low as 1 NIH U/ml)
C
Comparator
gamma-thrombin or PPACK-inactivated alpha-thrombin
O
Outcome
SMC migration and proliferationsurrogate
Alpha-thrombin stimulates vascular smooth muscle cell migration and proliferation, potentially via uPAR synthesis, suggesting a mechanism for atherosclerosis and restenosis after vascular injury.
Cite This Study
Noda-Heiny et al. (1995) studied this question.