February 1, 2017MedicineOpen Access

Effect of statin use on clinical outcomes in ischemic stroke patients with atrial fibrillation

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Why the study?

Does statin therapy reduce recurrent stroke or in-hospital death in ischemic stroke patients with atrial fibrillation?

Structured PICO

Does statin therapy reduce recurrent stroke or in-hospital death in ischemic stroke patients with atrial fibrillation?

Population

4,638 ischemic stroke patients with atrial fibrillation (from Taiwan National Health Insurance Database 2001-2011)

Intervention

Statin therapy initiated during the first 90 days after the index stroke

Comparator

No statin therapy during the first 90 days after the index stroke (matched 2:1 on age, sex, hypertension, diabetes mellitus, ischemic heart disease, heart failure, estimated NIHSS, anticoagulant use, and year of entry)

Outcome

First event of recurrent strokehard clinical

In patients with ischemic stroke and atrial fibrillation, initiating statin therapy within 90 days post-stroke does not reduce recurrent stroke risk but is associated with decreased in-hospital mortality.

Discussion

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Implication

Statin use after AF-related ischemic stroke was linked to lower mortality; leaves open effects on recurrence pending RCTs.

Cite This Study

Wu et al. (2017) studied this question.

synapsesocial.com/papers/6a7132de2163a0a01bc55d5f https://doi.org/10.1097/md.0000000000005918

Topics

Atrial fibrillation Statin therapy Anticoagulation in AF Persistent AF management Women and heart disease

View Full Paper

Ask AI

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Effect of statin use on clinical outcomes in ischemic stroke patients with atrial fibrillation

Structured PICO

Discussion

Implication

Cite This Study

Topics

Effect of statin use on clinical outcomes in ischemic stroke patients with atrial fibrillation

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider