Population
Rat ventricular myocytes and HEK-293 cells (human embryonic kidney cells) expressing RyR2
Design
Preclinical
Authors
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K201 may extend anti-arrhythmic mechanisms via FKBP12.6-independent RyR2 inhibition in myocytes; leaves open translation to intact hearts or patients.
K201 suppresses spontaneous Ca2+ release and RyR2 activity independently of FKBP12.6, suggesting an alternative mechanism for its anti-arrhythmic properties.
Hunt et al. (2007) studied this question.
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