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The metabolism of β 1C -globulin labeled with iodine-131 was studied in six normal individuals and in three individuals with glomerulonephritis who exhibited markedly reduced serum concentrations of this protein. Fractional catabolic rates were similar in both groups, and therefore the low concentration of serum β 1C -globulin in glomerulonephritis appears to be chiefly secondary to decreased synthesis.
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Alper et al. (1966) studied this question.
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