Mathematical modeling study demonstrates methods to quantify protein metabolic rates and capillary permeability in humans, rabbits, and rats, facilitating accurate compartmental analysis.
Using the tracer theory of Rescigno, adapted for an open mammillary system, a method is given of finding (1) metabolic rate, (2) ratios of masses of protein in extravascular compartments to mass of protein in intravascular compartment, (3) capillary permeabilities, when 131I-labelled protein is injected into the blood stream of animals. Examples are given for human, rabbit and rat.
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C. M. E. Matthews (1957) studied this question.
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