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September 1, 1970The Journal of PhysiologyOpen Access

The penetration of inulin, sucrose, mannitol and tritiated water from the interstitial space in muscle into the vascular system

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Population

Isolated gastrocnemius muscle from cat

Design

Preclinical

Authors

CCChristian CroneUniversity of CopenhagenDGD GarlickAustralian National University

Discussion

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Implication

Highlights interstitial gradients confounding tracer-based permeability assays; leaves open refined models before clinical translation.

Structured PICO

P
Population
Isolated gastrocnemius muscle from cat
I
Intervention
Perfusion with modified Ringer fluid containing extracellular tracers (mannitol, sucrose, inulin) and tritiated water (HTO), followed by tracer-free fluid
O
Outcome
Fractional rate of escape (Phi(t)) of the tracerssurrogate

The decline in the fractional rate of escape for extracellular tracers is caused by concentration gradients in the interstitial space, which has implications for methods studying capillary permeability.

Cite This Study

Crone et al. (1970) studied this question.

synapsesocial.com/papers/6a1f6e69019c3aaee5836a7ahttps://doi.org/10.1113/jphysiol.1970.sp009216
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Permeability of mammalian heart capillaries to sucrose and inulin1964 · 67 citations
  2. 2Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles1959 · 730 citations
  3. 3Cat Heart Muscle in Vitro1962 · 120 citations
  4. 4The partition of solutes between buffer solutions and solutions containing hyaluronic acid1961 · 282 citations
  5. 5Theoretical Considerations on Measurement of Capillary Diffusion Capacity in Skeletal Muscle by the Local Clearance Method1968 · 53 citations