Growth Cone Motility And Guidance

CONTENTS INTRODUCTION 43 SHAPE AND MOVEMENT: What are Growth Cones Really Like? 44 ULTRASTRUCTURE: Evidence of Membrane Recycling .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . 46 COMPOSITION: Do Growth Cone Specific Molecules Exist? ... . . . . . . . .... 47 PHYSIOLOGY: Ionic Signals That Stop a Growth Cone . . . . . . . . . 49 SECRETED PROTEASES: Do They Grease the Wheels? . . .. .... 5 1 GUIDANCE IN THE EMBRYO: Pathfinding in a Simple Vertebrate Embryo 53 GUIDANCE IN CULTURE: Contact Inhibition of Growth Cones .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 GUIDANCE MOLECULES: Axonal Pathways in Insect Embryos 57