Key result
Topical Sonic Hedgehog gene therapy accelerates wound recovery in diabetic mice by recruiting endothelial progenitor cells.
Why the study?
Diabetes is associated with impaired wound healing, and the potential of Sonic hedgehog pathway activation to enhance microvascular remodeling and accelerate wound closure was investigated.
Does topical Sonic hedgehog gene therapy accelerate wound healing in a diabetic mouse model?
Population
Diabetic mice with cutaneous wounds including Ptc1-LacZ and bone marrow transplantation models
Comparison
Topical gene therapy with naked DNA encoding Sonic hedgehog vs no gene therapy
Design
Preclinical experimental study
Authors
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No immediate clinical application in diabetic wounds; extends Sonic hedgehog research to cutaneous healing models.
Does topical Sonic hedgehog gene therapy accelerate wound healing in a diabetic mouse model?
Topical Sonic hedgehog gene therapy accelerates wound healing in diabetic mice by enhancing endothelial progenitor cell-mediated microvascular remodeling.
Asai et al. (2006) studied Diabetes and impaired cutaneous wound healing. Topical Sonic Hedgehog (Shh) gene therapy was evaluated on Wound recovery and vascularity. Topical Sonic Hedgehog gene therapy accelerated wound recovery and increased wound vascularity in diabetic mice by enhancing recruitment of endothelial progenitor cells.