Key result
Diabetes mellitus is associated with up to 80% of deaths via vascular disease and significantly reduces collateral blood vessel development in coronary or peripheral artery disease.
ardiovascular complications are the leading cause of morbidity and mortality in patients with diabetes mellitus; up to 80% of deaths in patients with diabetes are closely associated with vascular disease. The ability of the organism to form a collateral network of blood vessels constitutes an important response to vascular occlusive disease and determines to a large part the clinical consequences and severity of tissue ischemia. The development of new vessels is significantly reduced in diabetic patients with coronary or peripheral artery disease. This probably contributes to the severe course of limb ischemia in diabetic patients, in which peripheral artery disease often results in foot ulceration and lower extremity amputation.
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Silvestre et al. (2006) conducted a review in Diabetes mellitus with coronary or peripheral artery disease. Diabetes mellitus is associated with up to 80% of deaths via vascular disease and significantly reduces collateral blood vessel development in coronary or peripheral artery disease.
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