Why the study?
Does aminoguanidine improve ischemia-induced angiogenesis in diabetic mice?
Population
Mice with streptozotocin-induced diabetes and hindlimb ischemia induced by right femoral artery ligature.
Comparison
Aminoguanidine (AGEs formation blocker) 50 mg/kg vs Untreated diabetic mice and non-diabetic control…
Design
Preclinical
Follow-up
28 days post-ischemia
Authors
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May support AGE inhibition for diabetic ischemia models; leaves open human translation and safety.
Does aminoguanidine improve ischemia-induced angiogenesis in diabetic mice?
Blockade of advanced glycation end-product formation with aminoguanidine restores ischemia-induced angiogenesis in diabetic mice by normalizing matrix degradation processes.
Tamarat et al. (2003) studied this question.
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