Molecular assays detecting tumor-specific chimeric genes are valuable for diagnosing soft tissue sarcomas in unusual locations.
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May support molecular diagnosis of rare intraarticular masses; leaves open validation before routine clinical use.
A case of intraarticular synovial sarcoma arising in the knee verified by detection of the tumor-specific SYT-SSX fusion transcript is described. Although it is extremely rare, synovial sarcoma may occur entirely within a joint space. The molecular assay for detecting a tumor-specific chimeric gene is a valuable tool for diagnosis of soft tissue sarcoma, especially for diagnostically difficult cases and tumors in unusual locations.
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Namba et al. (2002) studied this question.
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