Key result
Expansive arterial remodeling is linked to heightened inflammation, protease activity, and thrombotic plaque phenotypes.
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The artery is a dynamic organ capable of changing its geometry in response to atherosclerotic plaque formation. Expansion of the vessel diameter retards luminal narrowing and is considered a compensatory response. However, the expansive remodeling response is a "wolf in sheep's clothes," because expansion is associated with the presence of inflammatory cells, proteolysis, and a thrombotic plaque phenotype. The prevalence and clinical presentation of expansively remodeled lesions may differ among vascular beds. However, it is evident that all types of atherosclerotic arterial expansive lesions share the presence of inflammatory cells and subsequent protease activities. The potential role of inflammation and protease activity in the development of the different remodeling modes is discussed.
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Pasterkamp et al. (2004) conducted a review in Atherosclerosis and expansive arterial remodeling. Expansive arterial remodeling in atherosclerosis is associated with inflammatory cells, protease activity, and a thrombotic plaque phenotype across vascular beds.
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