CRYing for balance: a repressor lingers through peak circadian transcription

Circadian rhythms in mammals rely on cell-autonomous molecular clocks that operate in many tissues and organs. New research in The EMBO Journal quantifies the expression dynamics, distribution, mobility, and turnover of circadian clock proteins in the suprachiasmatic nucleus. The quantitative data obtained from a physiologically relevant tissue will inspire tailored in vitro approaches and help to put these findings into a physiological context to further develop our current model of the circadian clock.