Why the study?
Does CYP2C19 genotype affect the proguanil metabolic ratio in a Caucasian population?
Does CYP2C19 genotype affect the proguanil metabolic ratio in a Caucasian population?
There is a CYP2C19 gene-dose effect for proguanil oxidation to cycloguanil, though substantial overlap exists between genotypes.
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CYP2C19 genotype affects proguanil metabolism in Caucasians; supports gene-dose effect but leaves open clinical relevance given overlap.
Hoskins et al. (1998) studied this question.
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