Why the study?
Do glucose dehydrogenase-based blood glucose meters improve performance compared to glucose oxidase-based meters at high altitude and low temperature?
Do glucose dehydrogenase-based blood glucose meters improve performance compared to glucose oxidase-based meters at high altitude and low temperature?
This study evaluates whether glucose dehydrogenase-based blood glucose meters perform more reliably than glucose oxidase-based meters under conditions of high altitude and low temperature.
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Glucose meter reliability at high altitude and low temperature remains uncertain; leaves open need for targeted validation before clinical recommendations.
Blood glucose meters using the enzyme glucose oxidase (GO) have been proven unreliable at high altitude (1–6). A new test strip technology, based on the oxygen-insensitive enzyme glucose dehydrogenase (GD), has been utilized by some manufacturers. Our hypothesis was that since oxygen is not involved in the reaction pathway of glucose dehydrogenase, glucose dehydrogenase-based blood glucose meters would perform better than glucose oxidase-based meters at high altitude. To our knowledge, performance of glucose dehydrogenase-based meters at high altitude and low temperature has not been studied. Five plasma-calibrated blood glucose meters were evaluated in this study, four glucose dehydrogenase based (GD1: Precision Xtra; GD2: Ascensia Contour; GD3: Accu-Chek Compact; and GD4: Freestyle) and one glucose oxidase …
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Öberg et al. (2005) studied this question.
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