Why the study?
Indirect MSFP estimation methods yield controversial results compared with zero-flow MSFP, and the discrepancy with inspiratory-hold MSFP depends on volume status.
Indirect estimates of mean systemic filling pressure are affected by underlying volume state and are unreliable compared to right atrial balloon occlusion in a porcine model.
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Volume status affects indirect MSFP agreement in pigs; leaves open optimal method selection for human use.
Möller et al. (2019) studied this question.
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