What question did this study set out to answer?

The study aims to evaluate the impact of ticlopidine on platelet activation induced by PAF-acether compared with other agonists.

April 24, 2009Haemostasis

Reduced Sensitivity of Human Platelets to PAF-Acether following Ticlopidine Intake

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Why the study?

Does Ticlopidine reduce platelet activation by PAF-acether, ADP, and AA in patients?

Population

9 patients

Comparison

Ticlopidine 250 mg b.i.d. for 7 days vs Before treatment (baseline)

Design

Cohort

Follow-up

7 days

Authors

MCMichel ChignardUniversité Paris-Sud CKC. Lalau KeralyUniversité Paris-Sud DDD. DelautierUniversité Paris-Sud

Discussion

Member takes

Implication

Ticlopidine may inhibit multiple platelet pathways in small cohorts; leaves open clinical benefit and requires larger prospective trials.

Key Points

The study aims to evaluate the impact of ticlopidine on platelet activation induced by PAF-acether compared with other agonists.
Nine patients received ticlopidine (250 mg b.i.d.) for 7 days.
Platelet aggregation was measured using PAF-acether, ADP, and arachidonic acid.
Statistical analyses included paired Student's t-test and two-way analysis of variance.
ADP-induced platelet aggregation was completely suppressed following ticlopidine treatment.
Arachidonic acid-induced aggregation was significantly inhibited (p < 0.05).
Ticlopidine treatment resulted in a significant inhibition of PAF-acether-induced aggregation.

Structured PICO

Does Ticlopidine reduce platelet activation by PAF-acether, ADP, and AA in patients?

Population

9 patients

Intervention

Ticlopidine 250 mg b.i.d. for 7 days

Comparator

Before treatment (baseline)

Outcome

Washed platelets activation by PAF-acether, adenosine 5'-diphosphate (ADP), and arachidonic acid (AA)surrogate

Ticlopidine exerts a persistent inhibitory effect on platelet aggregation induced by PAF-acether, ADP, and AA.

Cite This Study

Chignard et al. (2009) studied this question.

synapsesocial.com/papers/6a71398635aa2c282ce28948 https://doi.org/10.1159/000215919

Topics

Dual antiplatelet therapy

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Reduced Sensitivity of Human Platelets to PAF-Acether following Ticlopidine Intake

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Reduced Sensitivity of Human Platelets to PAF-Acether following Ticlopidine Intake

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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