August 25, 2006Diabetes CareOpen Access

Benfotiamine Prevents Macro- and Microvascular Endothelial Dysfunction and Oxidative Stress Following a Meal Rich in Advanced Glycation End Products in Individuals With Type 2 Diabetes

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Why the study?

Does benfotiamine prevent macro- and microvascular endothelial dysfunction following a high-AGE meal in individuals with type 2 diabetes?

Population

13 individuals with type 2 diabetes

Comparison

Benfotiamine 1,050 mg/day for 3 days prior to a… vs The same individuals before benfotiamine therapy

Follow-up

3 days of therapy, up to 6 hours postprandially

Authors

ASAlin StirbanBoehringer Ingelheim (Germany)MNMonica NegreanDiabetes Australia BSBernd StratmannJohannes Gutenberg University Mainz

Discussion

Member takes

Implication

May blunt postprandial endothelial dysfunction after high-AGE meals in T2D; leaves open effects on clinical outcomes.

Structured PICO

Does benfotiamine prevent macro- and microvascular endothelial dysfunction following a high-AGE meal in individuals with type 2 diabetes?

Population

13 individuals with type 2 diabetes

Intervention

Benfotiamine 1,050 mg/day for 3 days prior to a heat-processed test meal with high advanced glycation end product (AGE) content

Comparator

The same individuals before benfotiamine therapy (baseline response to the high AGE meal)

Outcome

Macrovascular flow-mediated dilatation (FMD) and microvascular reactive hyperemia measured at 2, 4, and 6 hours postprandiallysurrogate

Benfotiamine may prevent postprandial micro- and macrovascular endothelial dysfunction and oxidative stress induced by AGE-rich meals in patients with type 2 diabetes.

Cite This Study

Stirban et al. (2006) studied this question.

synapsesocial.com/papers/6a7139cbf44fa9f079df02a8 https://doi.org/10.2337/dc06-0531

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Benfotiamine Prevents Macro- and Microvascular Endothelial Dysfunction and Oxidative Stress Following a Meal Rich in Advanced Glycation End Products in Individuals With Type 2 Diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Benfotiamine Prevents Macro- and Microvascular Endothelial Dysfunction and Oxidative Stress Following a Meal Rich in Advanced Glycation End Products in Individuals With Type 2 Diabetes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider