Hunting the Chameleon: Structural Conformations of the Intrinsically Disordered Protein Alpha‐Synuclein

To illustrate the potential of labeling approaches in the field of intrinsically disordered proteins (IDPs), studies on α-synuclein (ASYN), one of the canonical model systems among the IDPs, are reviewed. ASYN displays a remarkable conformational flexibility, and depending on the molecular context, it adopts a variety of structurally distinct conformations resulting in the term “protein-chameleon”.