Why the study?
Does (+/-)-naringenin induce vasorelaxation and activate BKCa channels in rat vascular smooth muscle cells?
Population
Endothelium-denuded rat aortic rings and rat tail artery myocytes
Comparison
(+/-)-naringenin vs Control conditions, naringin, and various…
Design
Preclinical
Authors
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Supports BKCa-mediated vasorelaxation by naringenin in rat aorta; hypothesis-generating and requires human tissue validation before any clinical consideration.
Does (+/-)-naringenin induce vasorelaxation and activate BKCa channels in rat vascular smooth muscle cells?
(+/-)-naringenin acts as a vasorelaxant in endothelium-denuded vessels by activating BKCa channels in vascular smooth muscle cells.
Saponara et al. (2006) studied this question.
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