August 10, 2015Egyptian Journal of Medical Human GeneticsOpen Access

Cyclooxygenase 1 (COX1) expression in Type 2 diabetes mellitus: A preliminary study from north India

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Population

100 individuals from north India

Design

Case-control

Authors

SVSushma VermaJaypee Institute of Information Technology HCHoney Chandra MBMonisha BanerjeeUniversity of Lucknow

Discussion

Member takes

Implication

Elevated COX1 in T2DM samples may link oxidative stress to vascular risk; leaves open whether COX1 targeting improves outcomes.

Structured PICO

Population

100 individuals (50 Type 2 diabetes mellitus patients and 50 healthy sex/age matched controls) from north India

Comparator

Healthy sex/age matched controls

Outcome

COX1 mRNA expression and reactive oxygen species (ROS) levels in human macrophagessurrogate

COX1 expression and ROS levels are elevated in macrophages of T2DM patients, suggesting a potential role as a biomarker for oxidative stress and vascular complications in diabetes.

Limitations

small sample size
requires confirmation in other ethnic populations

Cite This Study

Verma et al. (2015) studied this question.

synapsesocial.com/papers/6a713e8ee5469ee92be1d326 https://doi.org/10.1016/j.ejmhg.2015.07.003

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Cyclooxygenase 1 (COX1) expression in Type 2 diabetes mellitus: A preliminary study from north India

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Cyclooxygenase 1 (COX1) expression in Type 2 diabetes mellitus: A preliminary study from north India

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider