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January 1, 2024Current Research in Pharmacology and Drug DiscoveryOpen Access

Quercetin prevents rats from type 1 diabetic liver damage by inhibiting TGF-ꞵ/apelin gene expression

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Why the study?

Hyperglycemia-induced oxidative stress contributes significantly to diabetic hepatopathy, motivating an evaluation of the ameliorative effect of quercetin on diabetes-induced liver functional disorders and tissue damage.

Does quercetin improve liver function and tissue damage in a rat model of type 1 diabetes?

Population

35 male Wistar rats

Comparison

Quercetin (25 or 50 mg/kg/day) vs diabetic control vs sham

Design

Animal experimental study

Follow-up

6 weeks

Authors

FGFirouzeh GholampourShiraz UniversityASA. Jones SusanShiraz UniversityZKZeinab KarimiShiraz University of Medical Sciences

Discussion

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Member takes

Implication

Quercetin may ameliorate diabetic hepatopathy in rats; leaves open clinical translation.

Structured PICO

Does quercetin improve liver function and tissue damage in a rat model of type 1 diabetes?

P
Population
35 male Wistar rats with streptozotocin (STZ)-induced type 1 diabetes
I
Intervention
Quercetin 25 mg/kg/day or 50 mg/kg/day in 1 ml 1% DMSO by gavage for 6 weeks
C
Comparator
Diabetic control (STZ only) and sham groups
O
Outcome
Liver functional disorders and tissue damage (including AST, ALT, ALP, bilirubin, lipids, oxidative stress markers, and apelin/TGF-ꞵ gene expression)surrogate

Quercetin ameliorates liver damage in a rat model of type 1 diabetes by reducing oxidative stress and inhibiting the apelin/TGF-ꞵ signaling pathway.

Cite This Study

Gholampour et al. (2024) studied this question.

synapsesocial.com/papers/6a713f4a35aa2c282ce28f32https://doi.org/10.1016/j.crphar.2024.100201
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Also Consider

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